WEBVTT 00:05.290 --> 00:08.160 Good morning everybody . No one says 00:08.160 --> 00:11.090 good morning anymore , good morning , 00:11.090 --> 00:14.100 thank you . Well thanks . I want to 00:14.100 --> 00:16.322 thank Carl and the rest of the team for 00:16.322 --> 00:18.211 doing this . I know everyone says 00:18.211 --> 00:20.211 thanks a lot but a lot does go into 00:20.211 --> 00:22.211 this on behalf of my boss , Colonel 00:22.211 --> 00:24.810 Grice . Um I'm in charge of the 00:24.810 --> 00:27.032 diagnostics detection division and I'll 00:27.032 --> 00:29.254 echo what john said , it's great to see 00:29.254 --> 00:31.199 everybody . I think these types of 00:31.199 --> 00:33.430 conferences are priceless to see the 00:33.430 --> 00:35.152 number of people and I will be 00:35.152 --> 00:37.208 embarrassing my folks , they already 00:37.208 --> 00:39.430 know that . So I'll be mentioning their 00:39.430 --> 00:41.541 names as we go through . When you put 00:41.541 --> 00:43.486 these things together , you have a 00:43.486 --> 00:45.900 certain script that you go through and 00:45.910 --> 00:48.140 certain when certain senior leaders um 00:48.150 --> 00:50.039 say certain things , it's kind of 00:50.039 --> 00:52.261 brings to light . Maybe I should change 00:52.261 --> 00:54.483 a little about what we're gonna do talk 00:54.483 --> 00:56.539 about . But fortunately a lot of the 00:56.539 --> 00:58.317 stuff we're working on in in in 00:58.317 --> 01:00.539 diagnostics and detection . Hit some of 01:00.539 --> 01:02.594 the priorities that Mr Watson talked 01:02.594 --> 01:06.350 about today . Um so the mission and and 01:06.350 --> 01:08.572 the vision of what we do is very simple 01:09.180 --> 01:11.013 In diagnostics and detection . I 01:11.013 --> 01:13.820 mentioned this in 2019 is our focus is 01:13.820 --> 01:15.987 to be able to enable the warfighter to 01:15.987 --> 01:18.153 see all threats inside the body and in 01:18.153 --> 01:20.376 the environment where the pivot will be 01:20.376 --> 01:22.264 is when we look at it from a more 01:22.264 --> 01:25.310 agnostic approach which will get to we 01:25.310 --> 01:27.550 want to develop innovative detection 01:27.550 --> 01:29.772 and diagnostic S and D capabilities and 01:29.772 --> 01:31.994 shout out to Colonel Grice for yes that 01:31.994 --> 01:33.939 was my cheesy joke but I'm full of 01:33.939 --> 01:36.250 cheesy jokes if you know me . Um we 01:36.250 --> 01:38.250 want to be able to better prepare , 01:38.250 --> 01:40.306 anticipate and respond to CB threats 01:40.306 --> 01:42.528 and we want to be able to fight and win 01:42.528 --> 01:44.694 and CB contested environments . We are 01:44.694 --> 01:44.610 in the war fighting business . I mean 01:44.610 --> 01:46.777 that's that's our job . What I'm gonna 01:46.777 --> 01:48.777 take you through is a couple of the 01:48.777 --> 01:51.020 highlights . Um And I have three 01:51.030 --> 01:52.919 capability areas , biological and 01:52.919 --> 01:55.470 chemical detection led by uh Mr Charles 01:55.470 --> 01:57.730 Hong was in the audience And then 01:57.730 --> 01:59.674 diagnostics , which is led by Miss 01:59.674 --> 02:01.730 Kathleen Quinn who's in the audience 02:01.730 --> 02:03.952 today . So I want to take you through a 02:03.952 --> 02:06.008 couple of the highlights where we've 02:06.008 --> 02:08.174 been actually some of the things we've 02:08.174 --> 02:10.770 done since 2019 take you where some of 02:10.770 --> 02:12.937 the gap areas we're trying to fill and 02:12.937 --> 02:14.881 then just end with the session the 02:14.881 --> 02:16.937 sessions to show you how we're tired 02:16.937 --> 02:18.937 altogether . Um These are one of my 02:18.937 --> 02:21.159 favorite charts and shout out to my A . 02:21.159 --> 02:23.326 And S . Death and put these together . 02:23.326 --> 02:25.492 These are my pipeline charts and where 02:25.492 --> 02:27.548 we were in the past is our detection 02:27.548 --> 02:29.603 models were very simple . See threat 02:29.603 --> 02:31.770 developed as 1/4 threat mission done . 02:31.770 --> 02:33.937 And in a lot of cases we've done a lot 02:33.937 --> 02:35.992 of good in that respect . But as the 02:35.992 --> 02:38.159 threat is adapted , we need to adapt . 02:39.100 --> 02:41.322 So we're trying to address the emerging 02:41.322 --> 02:43.656 enhanced threat and Colonel Grice adapt . 02:43.656 --> 02:45.489 We mentioned what we're doing in 02:45.489 --> 02:47.711 sequencing . It really started way back 02:47.711 --> 02:49.489 even before that in some of our 02:49.489 --> 02:51.544 bioinformatics work and did a lot of 02:51.544 --> 02:53.767 work with the Department of Energy Labs 02:53.767 --> 02:55.933 and MS Rosenblum mentioned their their 02:55.933 --> 02:58.100 power that a lot of work with the edge 02:58.100 --> 03:00.322 program . Somebody may be familiar with 03:00.322 --> 03:02.211 it and then moved into sequencing 03:02.211 --> 03:04.044 technology and now trying to get 03:04.044 --> 03:06.211 sequencing closer to the closer to the 03:06.211 --> 03:09.920 battlefield . And that's that's since 03:09.920 --> 03:12.142 2019 . That's that's really been moving 03:12.142 --> 03:14.364 forward and we're actually gonna have a 03:14.364 --> 03:16.476 field . We've had some demonstrations 03:16.476 --> 03:18.600 and some foldable prototypes and then 03:18.600 --> 03:20.767 as we move forward here , you're going 03:20.767 --> 03:22.822 to see this program called assays on 03:22.822 --> 03:24.656 demand . Where could we actually 03:24.656 --> 03:26.767 manufacture assays in the field which 03:26.767 --> 03:28.989 will reduce logistical burden . Right ? 03:28.989 --> 03:31.044 Not having , I can remember time not 03:31.044 --> 03:33.267 too long ago in my career I'm a retired 03:33.267 --> 03:35.322 Air Force officer like throwing away 03:35.322 --> 03:37.656 all these free agents that were expired . 03:37.656 --> 03:39.767 I'm talking just buckets of re agents 03:39.767 --> 03:41.878 that were expired and how could we do 03:41.878 --> 03:43.600 that and minimum minimize that 03:43.600 --> 03:45.489 logistical burden in the chemical 03:45.489 --> 03:47.656 detection space . Some of them some of 03:47.656 --> 03:49.822 the more near highlights are we've got 03:49.822 --> 03:51.822 two main programs which I'll talk a 03:51.822 --> 03:54.044 little bit more CV cod and cod that are 03:54.044 --> 03:57.500 really partnered strongly with R . J . 03:57.500 --> 04:00.420 P . O partners and with the combat 04:00.420 --> 04:02.200 vapor detector and the proximal 04:02.200 --> 04:04.311 chemical detector we think within the 04:04.311 --> 04:06.478 fight out we're gonna be fielding that 04:06.478 --> 04:08.533 technology . We also in the chemical 04:08.533 --> 04:10.533 space have pivoted to the emergency 04:10.533 --> 04:12.644 threatened PBS and have some programs 04:12.644 --> 04:15.030 um with companies like flair and a 04:15.030 --> 04:17.252 shout out to our industry partners . We 04:17.252 --> 04:19.308 wouldn't be as far along you have if 04:19.308 --> 04:21.363 you weren't there with us looking at 04:21.363 --> 04:23.474 this , looking at this threat . So we 04:23.474 --> 04:26.630 pivoted away from um the traditional 04:26.630 --> 04:28.930 threat that that's still there . But 04:28.930 --> 04:30.670 then moving to some of these 04:30.680 --> 04:33.890 disadvantage threat in PBS for example . 04:34.980 --> 04:37.202 So in biological detection , what's the 04:37.202 --> 04:39.313 moral of the story here ? We're going 04:39.313 --> 04:41.258 beyond the threat list . You heard 04:41.258 --> 04:41.240 Colonel Grice talk about targeted 04:41.240 --> 04:43.750 approaches Now we're going to 04:43.760 --> 04:46.530 untargeted approaches , Sequencing 04:46.530 --> 04:50.350 being done under six hours . Other 04:50.350 --> 04:53.790 agnostic methods . Looking at um 04:53.800 --> 04:56.530 things such again as a Cezanne demand 04:56.540 --> 04:59.160 moving away from pathogen directed 04:59.160 --> 05:01.540 identification . Okay , that's going to 05:01.540 --> 05:04.290 be a key component in the chemical 05:04.290 --> 05:06.512 space . Again , reducing the logistical 05:06.512 --> 05:08.960 burden on the person . We've actually 05:08.960 --> 05:11.130 with the C . V . Cap program have four 05:11.140 --> 05:13.307 prototypes in development with R . J . 05:13.307 --> 05:16.920 P . O . Partners trying to reduce 05:16.930 --> 05:19.740 um you know , the burden of the of the 05:19.740 --> 05:22.120 soldier or the airmen or the sailor of 05:22.120 --> 05:24.490 wearing that technology . And then 05:24.490 --> 05:27.610 looking at remote sensing or standoff , 05:27.610 --> 05:29.777 you see in the picture in the bottom , 05:29.777 --> 05:31.888 in the bottom right , doing that at a 05:31.888 --> 05:35.080 short 3 to 10 m distance for some of 05:35.080 --> 05:37.810 the detection topic areas you have . 05:37.820 --> 05:41.270 Just on my next slide , we've got four 05:41.270 --> 05:43.048 main topic areas we're gonna be 05:43.048 --> 05:46.840 discussion today and that's where when 05:46.840 --> 05:48.784 we go to these topic areas . We're 05:48.784 --> 05:52.650 trying to address the gaps that that Mr 05:52.650 --> 05:54.761 Watson talked about and Colonel Grice 05:54.761 --> 05:57.100 talked about and what we do is we have 05:57.100 --> 05:59.520 a mix of performers , people that we're 05:59.520 --> 06:01.353 funding but people that were not 06:01.353 --> 06:03.353 funding . What are those next novel 06:03.353 --> 06:05.900 ideas , what we talk about today in the 06:05.900 --> 06:07.844 coming days . What we see in these 06:07.844 --> 06:11.730 topic areas will help drive investment 06:11.740 --> 06:13.796 will say oh that is a good idea that 06:13.796 --> 06:15.740 addresses that . Yeah , that's the 06:15.740 --> 06:18.430 power of this meeting . Okay , so we've 06:18.430 --> 06:20.560 got on seven december from sensing to 06:20.560 --> 06:22.960 making sense . We've got Mr Tyler 06:22.960 --> 06:25.520 Miller and partnership with C B I . You 06:25.520 --> 06:27.990 heard uh Dr han and talk about the 06:27.990 --> 06:29.990 integration between the divisions . 06:29.990 --> 06:33.540 I'll let you read that um the next one 06:33.550 --> 06:35.950 um on nine december is next generation 06:35.950 --> 06:38.117 bio several detection identification . 06:38.117 --> 06:40.300 We do a great job with aerosol 06:40.300 --> 06:42.022 detection but not so much with 06:42.022 --> 06:43.856 identification . Can we actually 06:43.856 --> 06:45.578 identify ? And there's a clear 06:45.578 --> 06:49.240 distinguished in that syntax and in our 06:49.240 --> 06:51.240 community we sometimes confuse it . 06:52.770 --> 06:55.940 Okay , um the overall focus will see 06:55.950 --> 06:57.894 combining detection collection and 06:57.894 --> 06:59.820 identification of various agents 06:59.830 --> 07:02.470 potentially in class and the last one 07:02.470 --> 07:04.470 which is not listed here is genetic 07:04.470 --> 07:06.470 editing technology and detection of 07:06.470 --> 07:08.470 genetic editing technology on eight 07:08.470 --> 07:10.303 december . That's going to be in 07:10.303 --> 07:12.414 partnership with our cbs colleagues . 07:12.414 --> 07:14.637 You'll hear from dr Norwood as well and 07:14.637 --> 07:16.859 how we can detect these threats and you 07:16.859 --> 07:18.859 heard MS Rosenblum talk about those 07:18.859 --> 07:21.270 threats specifically . So as we move 07:21.270 --> 07:23.214 into diagnostics a lot has changed 07:23.214 --> 07:27.200 since 2019 as well . Most notably again 07:27.210 --> 07:29.099 moving away from passive directed 07:29.099 --> 07:31.830 identification . Two more of agnostic 07:31.830 --> 07:33.830 approaches . So I start on the left 07:33.830 --> 07:36.030 hand of the pipe here . That device on 07:36.030 --> 07:37.919 the upper left hand corner of the 07:37.919 --> 07:40.630 device was funded in large part by the 07:40.630 --> 07:42.910 funds provided by Mr Watson's office 07:42.910 --> 07:45.021 and now you can purchase one of those 07:45.021 --> 07:47.077 devices on G . S . A . And use it in 07:47.077 --> 07:49.188 your laboratory . Why ? How is that ? 07:49.188 --> 07:51.299 Well cool that's any other lab device 07:51.299 --> 07:53.466 but that will tell you if you've got a 07:53.466 --> 07:55.466 bacterial viral infection within 15 07:55.466 --> 07:57.577 minutes of of within the intended use 07:57.577 --> 07:59.632 collecting the sample . If we really 07:59.632 --> 08:01.688 want to push past the lip service of 08:01.688 --> 08:03.854 the advanced emerging threat that next 08:03.854 --> 08:05.966 virus . If you go to the I don't know 08:05.966 --> 08:05.920 how many people here have had kids with 08:05.920 --> 08:07.864 a runny nose and you bring them in 08:07.864 --> 08:10.230 right or you go see it sick and you go 08:10.230 --> 08:12.230 in . Well now it will tell you okay 08:12.230 --> 08:14.341 you've got a bacterial infection or a 08:14.341 --> 08:16.341 viral infection and now we give you 08:16.341 --> 08:18.341 antibiotics or we don't . The upper 08:18.341 --> 08:20.640 device here the N . G . D . Chemical DX 08:20.640 --> 08:22.751 is that I think is a great example of 08:22.751 --> 08:24.862 the of the strong partnership we have 08:24.862 --> 08:26.973 with advanced development and it's in 08:26.973 --> 08:28.973 that specific device in that little 08:28.973 --> 08:31.196 blue commoner type device . We actually 08:31.196 --> 08:33.418 jointly developed that with R . J . P . 08:33.418 --> 08:35.362 O . Colleagues and actually that I 08:35.362 --> 08:37.529 believe if I'm correct and mr Colvin's 08:37.529 --> 08:39.584 in the front so we can tell me no or 08:39.584 --> 08:41.640 not ? I think we we we we definitely 08:41.640 --> 08:43.973 hit milestone C . Or very close to that . 08:43.973 --> 08:45.918 And the feeling that very close to 08:45.918 --> 08:48.084 milestone C . Thank you sir in fy 24 . 08:48.084 --> 08:49.862 And that will be a field herbal 08:49.862 --> 08:51.918 technology looking at if you've been 08:51.918 --> 08:55.680 exposed to a chemical agent um Some 08:55.680 --> 08:57.736 other things . So we were addressing 08:57.736 --> 08:59.902 the emerging other things in here in a 08:59.902 --> 09:02.124 portfolio highlights . Um And I'll talk 09:02.124 --> 09:04.291 a little bit about it . But one of the 09:04.291 --> 09:06.513 things I want to just mention synthetic 09:06.513 --> 09:08.736 re agents for diagnostics that gets out 09:08.736 --> 09:10.680 to someone . Mr when Mr Watson was 09:10.680 --> 09:12.791 talking about as well we don't really 09:12.791 --> 09:14.902 have a platform technology to rapidly 09:14.902 --> 09:17.180 manufacture . Um Let's say we want 09:17.180 --> 09:20.430 lateral flow assays . We do traditional 09:20.440 --> 09:22.662 you know mammalian systems . What if we 09:22.662 --> 09:24.162 could do the whole process 09:24.162 --> 09:26.273 synthetically really would reduce the 09:26.273 --> 09:28.384 logistical burden while getting doing 09:28.384 --> 09:30.440 it very innovatively but also and um 09:30.980 --> 09:32.924 doing this platform very quickly . 09:32.924 --> 09:34.924 Maybe cutting it from six months to 09:34.924 --> 09:37.147 three months to six weeks . Some of the 09:37.147 --> 09:39.091 key areas of interest or minimally 09:39.091 --> 09:41.147 invasive testing methods again which 09:41.147 --> 09:43.369 will hit the logistical piece . I don't 09:43.369 --> 09:45.591 know about you but I don't like getting 09:45.591 --> 09:44.800 stuck with a needle . I had to get 09:44.800 --> 09:47.022 three vaccines before I came here and I 09:47.022 --> 09:49.244 couldn't stand it . Right so what about 09:49.244 --> 09:51.490 getting four bottom ease ? What if we 09:51.490 --> 09:53.970 could eliminate that breath rapid 09:53.970 --> 09:56.620 screening saliva micro needles . Trying 09:56.620 --> 09:58.842 to push the diagnostics far forward but 09:58.842 --> 10:01.640 trying minimally invasive means of um 10:01.650 --> 10:04.210 collection . And the other one here is 10:04.210 --> 10:06.750 treating the unknown threat bacterial 10:06.810 --> 10:09.040 viral presymptomatic and the other one 10:09.040 --> 10:13.020 is severity I think Colonel Grayson and 10:13.030 --> 10:15.720 and dr Hannah mentioned it too . For 10:15.720 --> 10:17.942 those of you that are medical folks out 10:17.942 --> 10:20.164 there we do a lot of you have heard the 10:20.164 --> 10:22.109 term combat triage . Well severity 10:22.109 --> 10:24.164 really is a way of triaging you . If 10:24.164 --> 10:26.220 you get afflicted with an illness we 10:26.220 --> 10:28.164 don't do that . But think about in 10:28.164 --> 10:30.310 covid how that would have helped not 10:30.310 --> 10:32.310 knowing you're gonna have let's say 10:32.310 --> 10:34.477 you're gonna get sick but how sick are 10:34.477 --> 10:36.643 you're gonna get if we could really do 10:36.643 --> 10:38.754 that . Think about the you know being 10:38.754 --> 10:40.866 able to fight and win in a contestant 10:40.866 --> 10:43.088 environment the troop the man and woman 10:43.088 --> 10:45.330 right getting back into the field . And 10:45.330 --> 10:47.274 then lastly just some of the topic 10:47.274 --> 10:49.910 areas we want to look at nontraditional 10:49.910 --> 10:52.021 approaches for that next breakthrough 10:52.021 --> 10:54.500 capability . The film array technology 10:54.500 --> 10:56.640 which by biofire which is which is a 10:56.640 --> 10:58.918 time tested technology works very well . 10:58.918 --> 11:01.084 It's going to obsolescence here before 11:01.084 --> 11:03.307 the end of the decade . What's going to 11:03.307 --> 11:05.529 be that revolutionary technology that's 11:05.529 --> 11:08.740 gonna get us into the 2030's And then 11:08.750 --> 11:10.861 which that'll be with their two parts 11:10.861 --> 11:12.694 is one on six December and seven 11:12.694 --> 11:16.010 December led by by by Kathleen Quinn 11:16.020 --> 11:18.187 and then we're toxins . That's an area 11:18.187 --> 11:20.930 we want to learn more about . We can do 11:20.930 --> 11:22.600 better in toxin detection and 11:22.600 --> 11:24.910 identification , both environmentally 11:24.920 --> 11:28.370 and using clinical samples . So on nine 11:28.370 --> 11:31.580 december 10 45 Dr delaney Wallace one 11:31.580 --> 11:34.840 of my stems . So wrap up with this and 11:34.840 --> 11:37.007 say thanks to everyone for coming . Is 11:37.007 --> 11:40.090 we have I mean thankfully thank you Mr 11:40.090 --> 11:42.257 Watson . We are doing addressing a lot 11:42.257 --> 11:44.280 of your areas already and we are 11:44.280 --> 11:46.224 pivoting , we've been pivoting for 11:46.224 --> 11:48.447 awhile to that to the advanced emerging 11:48.447 --> 11:50.502 threat and I know my teams out there 11:50.502 --> 11:52.690 looks forward to a hearty engagement 11:52.700 --> 11:54.811 with the with the community . At this 11:54.811 --> 11:56.978 point I'm going to turn it over to the 11:56.978 --> 11:58.922 chief of the Hazard protection and 11:58.922 --> 12:00.470 mitigation division . Dr Charles bass .