WEBVTT

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(upbeat tempo music)

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- Good afternoon.

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My name is Lieutenant
Colonel Barbara Cloutier,

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and I have the distinct
pleasure of leading

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the Premier Division in the
Chem/Bio Defense S and T program

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with the best team of
professionals in the industry,

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and all my CBS folks out there

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I'd like you to stand up

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and remain standing just for a second.

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Awe yah, awe yeah, yeah!

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(clapping)

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Unlike some of my fellow divisions.

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Very few entities outside
of the DOD do what we do.

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We're excited to spend this week

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developing new relationships
and expanding our ability

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to produce new options
for our warfighters.

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That's the team you need to go to when

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you have your disruptive ideas,

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bring them to them and they'll
put them into existence.

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Our mission is to protect
the warfighter by developing

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and transitioning novel
technologies to address current

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and emerging chemical
and biological threats.

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CBS is fully nested into the integrated

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early warning, integrated layer defense,

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and the prepare for surprise pillars

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of the CBS and T mission.

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We're divided into two teams,

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threat agent science and
chemical medical countermeasures.

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Threat agent science
validates the risks identified

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by collected intelligence.

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And that validated threat data

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drives the entire CB enterprise

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from development to operational
planning, risk mitigation

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and policy change for all of our divisions

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and the rest of the CB enterprise.

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Definitely, the tip of the spear.

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Our chemical countermeasures team

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develops prophylactic and
treatment options for both new

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and existing chemical threats.

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I will start with the
chemical countermeasures team.

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We work from the
identification of a new threat,

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through discovery and pre-clinical trials,

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to phase I clinical trials,

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and then we hand off to
an advanced developer.

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Our job is to de-risk
advanced development,

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discover novel platforms
and remove the advantage

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for our enemies that
chemical warfare produces.

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We are looking to expand
our options and partners

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at every one of the developmental
phases in our purview.

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This team works in the integrated
layer defense continuum

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as depicted in the upper left hand corner

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of the slide

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from preparation to
treatment and recovery.

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We divided our work into six thrust areas

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along that continuum, and
two supporting elements,

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and I will briefly describe each.

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Nerve agent prophylaxis
currently contains two programs,

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ACES and IMPaCT.

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These programs are
searching for additional

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catalytic scavengers, in the first

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and novel prophylactic
compounds in the second

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that can approach broad spectrum coverage

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from traditional chemical agents

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to pharmaceutical based agents
to new chemical threats,

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all in one chemical countermeasure.

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Can you find it?

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Neuroprotection focuses on
increasing quality of life

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and return to full
function should the need

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for chemical exposure treatment occur.

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Investigating compounds used
in other fields of medicine

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and converting them for use
in the chemical warfare realm,

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or producing novel compounds
that will change the paradigm

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from merely surviving following
good chemical exposure

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to preservation of neuronal structure.

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Crowd therapeutics is
searching to fill the gaps

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that are currently deployed,
decon solution RSDL leaves

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an ocular wound and whole body decon.

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Nerve agent therapeutic
thrust area includes INATS,

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where the goal is to
provide rapid treatment

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to counter effects from
exposure to chemical threats,

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ensure protection of the
central nervous system,

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against organophosphorous agents

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and develop broad spectrum
cholinesterase reactivators.

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Other CWA therapeutics covers
just what it says there

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on the slide, mustard and
cyanide treatment work.

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We still haven't resolved those.

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A robust pharmaceutical
based agent thrust area

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currently spans the entire
spectrum of this newer threat,

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seeking to repurpose opioid
receptor antagonists,

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develop non-antagonist therapeutics

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against opioid based chemical threats

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and expand non-opioid
countermeasure development

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for novel pharmaceutical agents.

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Since we sit in a space
where few are doing work

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in chemical warfare agent countermeasures,

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we also have two enabling thrust areas.

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We use both our enabling
science and our basic research

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to utilize novel technology
like artificial intelligence

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and multifunctional delivery platforms,

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explore compounds with
longer duration of action

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for next generation
therapeutic or prophylaxis,

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establish human equivalent
doses from animal models

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and extrapolate them to
human dose requirements,

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to explore other approved
drugs or compounds

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with existing data to improve
upon existing treatments

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or to treat new and emerging threats.

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And of course to capitalize
on the data produced

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by our threat agent science team.

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Our threat agent science
team deals with both chemical

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and biological threats.

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They translate intelligence community

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or IC threat brief
information into research.

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With a two way communication with IC

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as results are obtained
we enabled the refinement

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of that brief.

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Information produced is used by the IC

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and the larger Chem/Bio enterprise

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to influence capability
development, doctrine,

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and every other aspect of our
integrated layered defense,

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integrated early warning and preparation

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for surprise activities.

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Leading the DOD science
and technology programs

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to anticipate, defend and safeguard

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against chemical and biological threats

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for the warfighter and the nation.

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In Doctor Hans words,
"Preparing for the unthinkable".

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Threat agent science makes our enterprise

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agile and adaptable.

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This team divides this
work into five thrust areas

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with one enabling thrust
area and by basic research.

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Technical surprise uses
horizon scanning studies

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and technical advanced impact studies

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to find out what tech
advances do we really need

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to run through our
evaluation assessment plan.

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It's fed by both the IC and
our own highly intelligent

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teams monitoring.

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First look evaluates the
synthesis and characterization

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of non-traditional agents,
pharmaceutical based agents,

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and emerging biological threats.

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Can we make it?

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What does it look, feel and behave like?

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And is it even toxic to people?

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The environmental thrust response area

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provides the aerosol, dissemination
and atmospheric studies,

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the molecular fate and persistence

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in the environment information
and particle resuspension

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and reaerosolization.

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What does it behave
like in the environment?

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Can we get rid of it?

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Does it pose a long term health
hazard, or does it degrade?

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Some of the information that you heard

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John Hannon talk about that
he's put into the H-pack

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and the other evaluating information

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so that we can provide
good threat assessments

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and movement and changes to people's

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operational requirements
on the battlefield.

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Our basic research focuses
on aerosol science,

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bio survivability and systems
biology of potential threats.

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These are the leads of my teams.

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CBS is excited to present
details of several

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of our thrust areas this
week as we endeavor to find

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new partners, to help us
speed up the production

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of options to protect those warfighters

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that we were all talking
about all day today.

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The added advantage and
our special theory for us

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and for our partners is the
dual utility of our work

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with the first responders.

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We look forward to this
week advancing science

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and technology and
developing new relationships,

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so that we can disrupt the enemies

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that try and attack us.

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Thank you.

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(upbeat tempo music)